There is considerable research on each of our three amazing ingredients and their positive effects on the skin and body. We have selected the six most recent, clinical, placebo-controlled trials for each. If you would like the full list, please email: firstname.lastname@example.org
- Cosgrove, M.C. et al., 2007, Dietary nutrient intakes and skin-aging appearance among middle-aged American women. American Journal of Clinical Nutrition, 86 (4): 1225-1231
- Asserin, J. et al., 2015. The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: evidence from an ex vivo model and randomized, placebo-controlled clinical trials. Journal of Cosmetic Dermatology, doi: 10.1111/jocd.12174
- Clinical study, Cosderma, France, 2012
- Clinical study YNTKK – 2008 – 4144, Souken, Japan
- Clinical study 2008 – A00654 – 51, Dermscan, France
- Ohara H, Ichikawa S, Matsumoto H, Akiyama M, Fujimoto N, Kobayashi T, Tajima S, 2010. Collagen derived dipeptide, proline-hydroxyproline, stimulates cell proliferation and hyaluronic acid synthesis in cultured human dermal fibroblasts. J Dermato 374: 330-338
- Tominaga K et al., Cosmetic benefits of astaxanthin on human subjects. Acta Biochim Pol. 2012;59(1):43-7.
- Suganuma K et al., Anti-aging and functional improvement effects for the skin by functional food intake: clinical effects on skin by oral ingestion of preparations containing Astaxanthin and Vitamins C and E. Jichi Medical University Journal. 2012;35:25-33.
- Tominaga K et al., Cosmetic effects of astaxanthin for all layers of skin. Food Style 21. 2009;13(10):25-9.
- Satoh A et al., Effect of the intake of astaxanthin containing Haematococcus pluvialis extract on the severity, immunofunction and physiological function in patients with atopic dermatitis. Jpn J Environ Dermatol Cutan Allergol. 2009;3(5):429-38.
- Yamashita E, The effects of a dietary supplement containing astaxanthin on skin condition. Carotenoid Science. 2006;10:91-5.
- Camera E et al. Astaxanthin, canthaxanthin and b-carotene differently affect UVA-induced oxidative damage and expression of oxidative stress-responsive enzymes. Experimental Dermatology, 18, 222–231
- Meyer LJM et al. “Age-dependent changes of hyaluronan in human skin.” Journal of Investigative Dermatology. 1994;102:385-389.
- Sakai S et al. “Hyaluronan exists in the normal stratum corneum.” Journal of Investigative Dermatology. 2000;114:1184-1187.
- Meyer LJM et al. “Reduced hyaluronan in keloid tissue and cultured keloid fibroblasts.” Journal of Investigative Dermatology. 2000;114:953-959.
- Wakayama S, presenter. “Clinical study on demonstrates improvement of skin moisture content.” Poster session presented at the March 2009 Nutracon and SupplyExpo conference, Anaheim, CA.
- Tashiro T et al. “Oral administration of polymer hyaluronic acid alleviates symptoms of knee osteoarthritis: a double blind, placebo controlled study over a 12 month period.” Scientific World Journal. 2012;2012: 167928
- Mariko Oe et al. “Oral hyaluronan relieves knee pain: a review”. Nutr J. 2016; 15: 11.